许琳，1992年生，安徽合肥人，本科毕业于安徽医科大学，硕士毕业于山东大学，博士和博士后均在必威官方网站。现为bw必威副教授，硕士生导师。
一、研究方向：肝脏毒理学，表观遗传（非编码小RNA），肝脏类器官
二、主要科研项目
1. 国家自然科学基金委面上项目，49万，在研，主持。
2. 国家自然科学基金委青年项目，30万，结题，主持。
3. 中国博士后面上项目，8万，结题，主持。
三、近五年代表性科研成果
<1> Wanli Ma , Xiaoyu Huo , Ruoxi Li , Jingjing Xing , Lin Xu#, Dianke Yu. piR-16404 drives ferroptotic liver injury via CASTOR1/mTORC1/GPX4 dysregulation in HepG2 cells and mice: a novel toxicity mechanism of N, N-dimethylformamide. Arch Toxicol. 2026. (IF=10.7).
<2>. Xu L, Ma W, Huo X, Luo J, Li R, Zhu X, Kong X, Zhao K, Jin Y, Zhang M et al: New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM(2.5)-induced lung cancer. J Adv Res 2024. (IF=11.4)
<3>. Ma W*, Xu L*, Wang Y, Chen S, Li D, Huo X, Li R, Zhu X, Chen N, Jin Y et al: piR-27222 mediates PM(2.5)-induced lung cancer by resisting cell PANoptosis through the WTAP/m(6)A axis. Environment international 2024, 190:108928. (IF=10.3)
<4>. Xu L*, Li Y*, Ma W, Sun X, Fan R, Jin Y, Chen N, Zhu X, Guo H, Zhao K et al: Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk. Journal of hazardous materials, 2023, 458:132060. (IF=12.2).
<5>. Fan R*, Xu L*, Cui B, Li D, Sun X, Qi Y, Rao J, Wang K, Wang C, Zhao K et al: Genomic Characterization Revealed PM(2.5)-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B. Environmental science & technology 2023, 57(17):6854-6864. (IF=10.9).
<6>. Xu L*, Ma W*, Jin Y, Sun X, Chen N, Zhu X, Luo J, Li C, Zhao K, Zheng Y et al: N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro. The Science of the total environment 2022, 839:156218. (IF=9.8).
<7>. Ma W*, Xu L*, Sun X, Qi Y, Chen S, Li D, Jin Y, Chen N, Zhu X, Luo J et al: Using a human bronchial epithelial cell-based malignant transformation model to explore the function of hsa-miR-200 family in the progress of PM(2.5)-induced lung cancer development. Environmental pollution (Barking, Essex : 1987) 2023, 319:120981. (IF=8.9).
<8>. Xu L*, Sun X*, Wang Y, Zhou T, Jia J, et al: Functional polymorphisms in Benzo(a)Pyrene-induced toxicity pathways associated with the risk on laryngeal squamous cell carcinoma. Food and Chemical Toxicology, 2023. (IF=3.9).
<9>. Xu L, Chen W, Chen J, Jin Y, Ma W, Qi G, Sun X, Luo J, Li C, Zhao K et al: PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A. Biochemical pharmacology 2021:114897. (IF=5.3).
<10>. Xu L*, Zhao Q*, Luo J, Ma W, Jin Y, Li C, Hou Y, Feng M, Wang Y, Chen J et al: Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity. Ecotoxicology and environmental safety 2020, 205:111166. (IF=6.2).
四、主要学术兼职
中国毒理学会类器官与器官芯片毒理学专业委员会委员
五、联系方式
xulin992@163.com
